Why overpay for Peyton Manning at the highest pick/salary for a QB when you can get close to or at the same level of production in a later round with a guy like Drew Brees? Look, Reggie Wayne and Antonio Gates look so tempting to grab immediately, but after week 17, are these the two guys that are going to be the far and away points leaders at their positions, worthy of a very high pick?
Look for these guys to get dumped when impatient owners panic as they dont live up to last year's numbers and pick them up as your backups immediately if you dont already have them: Ryan Grant, Derek Anderson, Shaun McDonald, Justin Fargas, Earnest Graham, to name just a few. Your biggest steals via trades or waivers is guys who did well last year but who defenses have figured out this year. Talking to you Vikings running game facing 8 men in the box every down, even third.
Draft WRs with experience! Only 6 of the top 25 fantasy scoring WRs in the NFL last year were players in the league three years or less. Rookies are tall and fast because of their youth and because the top picks are usually not smallish guys. What does that have to do with route running or a QB's confidence in throwing the ball to him on any type of regular basis, especially in the red zone?
Be ready for teams dumping underperforming players from the following teams before those teams week 4 byes hit: Lions, Colts, Dolphins, Patriots, Giants, Seahawks.
Keep on eye on this website throughout the year: http://www.theredzone.org/strength.asp This is the NFL strength of schedule which besides knowing who has byes each week is the second most important thing to be aware of before you pick up new players you didnt draft, and you even should consider it before you draft Steeler's players for example, who have a brutal schedule to deal with.